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A double-blind, placebo-controlled study evaluating the effects of caffeine and l-theanine both alone and in combination on cerebral blood flow, cognition and mood

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ROS can stimulate microglia to release inflammatory factors such as interleukin‐1α (IL‐1α), interleukin‐1β (IL‐1β), and tumor necrosis factor‐α (TNF‐α), which cause the activation of neuroimmune cells (such as astrocytes) [207], triggering the innate immune response